Potential use of selective and nonselective Pim kinase inhibitors for cancer therapy

J Med Chem. 2012 Oct 11;55(19):8199-208. doi: 10.1021/jm3009234. Epub 2012 Sep 4.

Authors

Denis Drygin¹, Mustapha Haddach, Fabrice Pierre, David M Ryckman

Affiliation

¹ Cylene Pharmaceuticals, 5820 Nancy Ridge Drive, Suite 200, San Diego, CA 92121, USA.

PMID: 22924342
DOI: 10.1021/jm3009234

No abstract available

MeSH terms

Animals
Antineoplastic Agents / chemistry*
Antineoplastic Agents / therapeutic use
Humans
Isoenzymes / antagonists & inhibitors
Isoenzymes / chemistry
Isoenzymes / physiology
Neoplasms / drug therapy*
Neoplasms / enzymology
Protein Conformation
Proto-Oncogene Proteins c-pim-1 / antagonists & inhibitors*
Proto-Oncogene Proteins c-pim-1 / chemistry
Proto-Oncogene Proteins c-pim-1 / physiology
Signal Transduction

Substances

Antineoplastic Agents
Isoenzymes
Proto-Oncogene Proteins c-pim-1
proto-oncogene proteins pim